Zinc Oxide Nanoparticles Modified with Galactose as Potential Drug Carrier with Reduced Releasing of Zinc Ions

The toxicity of bare zinc oxide nanoparticles used as drug carriers may be the result of releasing zinc ions. Thus, zinc oxide nanoparticles modified with galactose were obtained. The process of their formation was conducted in the microwave field. The physicochemical properties of the obtained products were studied. The size and electrokinetic potential were defined by using dynamic light scattering technique. The crystalline properties were assessed by X-ray diffractometry. In order to confirm the formation of the desired products, Fourier-transform infrared spectroscopy was used. Releasing of zinc ions from the prepared products when comparing to the bare oxide was analyzed. It was found out that modification of zinc oxide nanoparticles with galactose limits the releasing of zinc ions which are responsible for the toxic effect of the whole carrier-drug conjugate.

• Jolanta Pulit-Prociak
• Olga Długosz
• Marcin Banach

• Nanomaterials
• zinc oxide
• drug delivery system
• toxicity.

[1] J. Kumar Patra, G. Das, L.F. Fraceto, E. Vangelie Ramos Campos, M. del Pilar Rodriguez-Torres, L.S. Acosta-Torres, L.A. Diaz-Torres, R. Grillo, M. Kumara Swamy, S. Sharma, S. Habtemariam, H.S. Shin, “Nano based drug delivery systems: recent developments and future prospects”, Journal of Nanobiotechnology, vol. 16, pp. 1-33, 2018.
[2] S.J. Soenen, W.J. Parak, J., Rejman, B. Manshian, “(Intra)Cellular stability of inorganic nanoparticles: Effects on cytotoxicity, particle functionality, and biomedical applications”, Chemical Reviews, vol. 115, pp. 2109-2135, 2015.
[3] H.L. Karlsson, M.S. Toprak, B. Fadeel, “Chapter 4 - Toxicity of Metal and Metal Oxide Nanoparticles”, in: Handbook on the Toxicology of Metals (Fourth Edition), vol. I, pp. 75-112, 2015.
[4] I-L. Hsiao, Y.-J. Huang, “Titanium oxide shell coatings decrease the cytotoxicity of ZnO nanoparticles”, Chemical Research in Toxicology, vol. 24, pp. 303–313, 2011.
[5] T. Xia, Y. Zhao, T. Sager, S. George, S. Pokhrel, N. Li, D. Schoenfeld, H. Meng, S. Lin, X. Wang, M. Wang, Z. Ji, J.I. Zink, L. Mädler, V. Castranova, S. Lin, A.E. Nel, “Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos”, ACS Nano, vol. 22, pp. 1223-1235, 2011.
[6] B. Wang, Y. Zhang, Z. Mao, D. Yu, C. Gao, “Toxicity of ZnO nanoparticles to macrophages due to cell uptake and intracellular release of zinc ions”, Journal of Nanoscience and Nanotechnology, vol. 14, pp. 5688-5696, 2014.
[7] H. Papavlassopoulos, Y.K. Mishra, S. Kaps, I. Paulowicz, R. Abdelaziz, M. Elbahri, E. Maser, R. Adelung, C. Röhl, “Toxicity of Functional Nano-Micro Zinc Oxide Tetrapods: Impact of Cell Culture Conditions, Cellular Age and Material Properties”, PlosOne, vol. 13, e84983, 2014.