Thermo-Mechanical Characterization of Skin Laser Soldering using Au Coated SiO2 Nanoshells
Gold coated silica core nanoparticles have an optical
response dictated by the plasmon resonance. The wavelength at
which the resonance occurs depends on the core and shell sizes,
allowing nanoshells to be tailored for particular applications. The
purposes of this study was to synthesize and use different
concentration of gold nanoshells as exogenous material for skin
tissue soldering and also to examine the effect of laser soldering
parameters on the properties of repaired skin. Two mixtures of
albumin solder and different concentration of gold nanoshells were
prepared. A full thickness incision of 2×20 mm2 was made on the
surface and after addition of mixtures it was irradiated by an 810nm
diode laser at different power densities. The changes of tensile
strength σt due to temperature rise, number of scan (Ns), and scan
velocity (Vs) were investigated. The results showed at constant laser
power density (I), σt of repaired incisions increases by increasing the
concentration of gold nanoshells, Ns and decreasing Vs. It is therefore
important to consider the trade off between the scan velocity and the
surface temperature for achieving an optimum operating condition. In
our case this corresponds to σt =1610 gr/cm2 at I~ 60 Wcm-2, T ~
65ºC, Ns =10 and Vs=0.2mms-1.
[1] M.Gulsoy , Z.Dereli , H.Tabakogh, "closure of skin incisions by 980 nm
diode laser welding". Lasers Med Sci ., vol.2, no.1, pp. 5-10 2006.
[2] M.McNally, B.S.Sorg , E.K.Chan , A.J.Welch , J.M.Dawes, "Optimal
parameters for laser tissue soldering. Part I: Tensile strength and
scanning electron microscopy analysis". Lasers Surg Med., vol. 26, no.4,
pp. 346 - 356,2000.
[3] S.D. DeCoste, W. Farinelli, T. Flotte, R.R. Anderson , "Dye enhanced
laser welding for skin closure". Lasers Surg Med., vol. 12, no.1, pp. 25-
32,1992.
[4] L.S. Bass , "Laser tissue welding: A comprehensive review of current
and future clinical applications", Lasers Surg Med., vol.17, no.4,
pp.315-349, 1995.
[5] D.Spector, Y.Rabi, I.Vasserman, ,A. Hardy, J.Klausner,A. Katzir, " In
vitro large diameter bowel anastomosis using a temperature controlled
laser tissue soldering system and albumin stent",Lasers Surg Med., vol.
41, no.7, pp.504-508,2009.
[6] A.C.O'Neill, J.M.Winograd, J.L.Zeballos, M.A.Randolph, K.E.Bujold,
I.E.Kochevar, R.W.Redmond, "Microvascular anastomosis using a
photochemical tissue bonding technique". Lasers Surg Med., vol.39,
no.9, pp. 716 - 722,2007
[7] B.Zuger, B.Ott, Th. Schaffner, J.Clemence, " Laser solder welding of
articular cartilage: Tensile strength and chondrocyte viability". Lasers
surg Med ., vol.28, no.5,pp.427-434,2001.
[8] D.Simhon, M. Halpern.,T. Brosh, T.Vasilyev, N.Kariv, R.Argaman,
A.Katzir , "In vivo laser soldering of incisions in juvenile pig skin, using
GaAs or CO2 lasers and a temperature control system", SPIE Proc. vol.
5312, pp.162-175,2004.
[9] M.E.Khosroshahi, M.S.. Nourbakhsh, S. Saremi, F. Tabatabaee F,
"Characterization of skin tissue soldering using diode laser and ICG: Invitro
studies", Laser Med Sci., vol.25,no.2, pp.207-212, 2010.
[10] D.Duff, A.Baiker,P.Edwards, "A new hydrogel of gold cluster formation
and particle size variation", Langmuir, vol.9, no.9, pp.2301-2309,1993.
[11] J.M. Stern, J.Stanfield ,W. Kabbani , "Selective prostate cancer thermal
ablation with laser activated gold nanoshells". J Urol., vol. 179, no.2,
pp.748-753,2008.
[12] Y.Wang, W.Qian, Y.Tan , "A label-free biosensor based on gold
nanoshell monolayers for monitoring biomolecular interactions in
diluted whole blood". Biosens Bioelectron vol.23, no.7, pp.1166-1170,
2008.
[13] L.R.Hirsch, R.J. Stafford, J.A. Bankson, S.R. Sershen,
B.Rivera,R.E.Price, J.D.Hazle , N.J.Halas, J.L.West , "Nanoshellmediated
near-infrared thermal therapy of tumors under magnetic
resonance guidance" , Proc. Natl.Acad .Sci. USA,vol. 100,
no.23,pp.13549-13554, 2003.
[14] D.P.O-Neal , L.R.Hirsch , N.J.Halas, J.D. Payne ,"Photothermal tumor
ablation in mice using near infrared-absorbing nanoparticles", Cancer
Lett ., vol. 209, no.2, pp.171-176.2004.
[15] D.K. Dew, R.Serbent, W.S.Hart, G.C. Boynton, J.D.Byrne ,J.G.Evans
"Laser assisted microsurgical vessel anastomosis techniques: The use of
argon and CO2 lasers". Lasers Surg Med , vol.3, no.2, pp.135-137,
1983.
[16] M.S.Nourbakhsh, M.E.Khosroshahi,, S. Saremi, F. Tabatabaee F., "
Effect of static and dynamic modes on laser tissue soldering: an in-vitro
study", NBC proceedings vol.20, pp.2383-385, 2008.
[17] R.A.Alvarez-Puebla, D.J.Ross, G.A.Nazri, R.F.Aroca , "Surface-
Enhanced Raman Scattering on Nanoshells with Tunable Surface
Plasmon Resonance", Langmuir , vol.21, no.23, pp. 10504-10508, 2005.
[1] M.Gulsoy , Z.Dereli , H.Tabakogh, "closure of skin incisions by 980 nm
diode laser welding". Lasers Med Sci ., vol.2, no.1, pp. 5-10 2006.
[2] M.McNally, B.S.Sorg , E.K.Chan , A.J.Welch , J.M.Dawes, "Optimal
parameters for laser tissue soldering. Part I: Tensile strength and
scanning electron microscopy analysis". Lasers Surg Med., vol. 26, no.4,
pp. 346 - 356,2000.
[3] S.D. DeCoste, W. Farinelli, T. Flotte, R.R. Anderson , "Dye enhanced
laser welding for skin closure". Lasers Surg Med., vol. 12, no.1, pp. 25-
32,1992.
[4] L.S. Bass , "Laser tissue welding: A comprehensive review of current
and future clinical applications", Lasers Surg Med., vol.17, no.4,
pp.315-349, 1995.
[5] D.Spector, Y.Rabi, I.Vasserman, ,A. Hardy, J.Klausner,A. Katzir, " In
vitro large diameter bowel anastomosis using a temperature controlled
laser tissue soldering system and albumin stent",Lasers Surg Med., vol.
41, no.7, pp.504-508,2009.
[6] A.C.O'Neill, J.M.Winograd, J.L.Zeballos, M.A.Randolph, K.E.Bujold,
I.E.Kochevar, R.W.Redmond, "Microvascular anastomosis using a
photochemical tissue bonding technique". Lasers Surg Med., vol.39,
no.9, pp. 716 - 722,2007
[7] B.Zuger, B.Ott, Th. Schaffner, J.Clemence, " Laser solder welding of
articular cartilage: Tensile strength and chondrocyte viability". Lasers
surg Med ., vol.28, no.5,pp.427-434,2001.
[8] D.Simhon, M. Halpern.,T. Brosh, T.Vasilyev, N.Kariv, R.Argaman,
A.Katzir , "In vivo laser soldering of incisions in juvenile pig skin, using
GaAs or CO2 lasers and a temperature control system", SPIE Proc. vol.
5312, pp.162-175,2004.
[9] M.E.Khosroshahi, M.S.. Nourbakhsh, S. Saremi, F. Tabatabaee F,
"Characterization of skin tissue soldering using diode laser and ICG: Invitro
studies", Laser Med Sci., vol.25,no.2, pp.207-212, 2010.
[10] D.Duff, A.Baiker,P.Edwards, "A new hydrogel of gold cluster formation
and particle size variation", Langmuir, vol.9, no.9, pp.2301-2309,1993.
[11] J.M. Stern, J.Stanfield ,W. Kabbani , "Selective prostate cancer thermal
ablation with laser activated gold nanoshells". J Urol., vol. 179, no.2,
pp.748-753,2008.
[12] Y.Wang, W.Qian, Y.Tan , "A label-free biosensor based on gold
nanoshell monolayers for monitoring biomolecular interactions in
diluted whole blood". Biosens Bioelectron vol.23, no.7, pp.1166-1170,
2008.
[13] L.R.Hirsch, R.J. Stafford, J.A. Bankson, S.R. Sershen,
B.Rivera,R.E.Price, J.D.Hazle , N.J.Halas, J.L.West , "Nanoshellmediated
near-infrared thermal therapy of tumors under magnetic
resonance guidance" , Proc. Natl.Acad .Sci. USA,vol. 100,
no.23,pp.13549-13554, 2003.
[14] D.P.O-Neal , L.R.Hirsch , N.J.Halas, J.D. Payne ,"Photothermal tumor
ablation in mice using near infrared-absorbing nanoparticles", Cancer
Lett ., vol. 209, no.2, pp.171-176.2004.
[15] D.K. Dew, R.Serbent, W.S.Hart, G.C. Boynton, J.D.Byrne ,J.G.Evans
"Laser assisted microsurgical vessel anastomosis techniques: The use of
argon and CO2 lasers". Lasers Surg Med , vol.3, no.2, pp.135-137,
1983.
[16] M.S.Nourbakhsh, M.E.Khosroshahi,, S. Saremi, F. Tabatabaee F., "
Effect of static and dynamic modes on laser tissue soldering: an in-vitro
study", NBC proceedings vol.20, pp.2383-385, 2008.
[17] R.A.Alvarez-Puebla, D.J.Ross, G.A.Nazri, R.F.Aroca , "Surface-
Enhanced Raman Scattering on Nanoshells with Tunable Surface
Plasmon Resonance", Langmuir , vol.21, no.23, pp. 10504-10508, 2005.
@article{"International Journal of Chemical, Materials and Biomolecular Sciences:55670", author = "M.S.Nourbakhsh and M.E.khosroshahi", title = "Thermo-Mechanical Characterization of Skin Laser Soldering using Au Coated SiO2 Nanoshells", abstract = "Gold coated silica core nanoparticles have an optical
response dictated by the plasmon resonance. The wavelength at
which the resonance occurs depends on the core and shell sizes,
allowing nanoshells to be tailored for particular applications. The
purposes of this study was to synthesize and use different
concentration of gold nanoshells as exogenous material for skin
tissue soldering and also to examine the effect of laser soldering
parameters on the properties of repaired skin. Two mixtures of
albumin solder and different concentration of gold nanoshells were
prepared. A full thickness incision of 2×20 mm2 was made on the
surface and after addition of mixtures it was irradiated by an 810nm
diode laser at different power densities. The changes of tensile
strength σt due to temperature rise, number of scan (Ns), and scan
velocity (Vs) were investigated. The results showed at constant laser
power density (I), σt of repaired incisions increases by increasing the
concentration of gold nanoshells, Ns and decreasing Vs. It is therefore
important to consider the trade off between the scan velocity and the
surface temperature for achieving an optimum operating condition. In
our case this corresponds to σt =1610 gr/cm2 at I~ 60 Wcm-2, T ~
65ºC, Ns =10 and Vs=0.2mms-1.", keywords = "Tissue soldering, Diode laser, Gold Nanoshells,Tensile strength", volume = "4", number = "4", pages = "252-4", }