Synthesis of Cross-Linked Konjac Glucomannan and Kappa Carrageenan Film with Glutaraldehyde

Cross-linked konjac glucomannan and kappa carrageenan film were prepared by chemical crosslinking using glutaraldehyde (GA) as the crosslinking agent. The effect crosslinking on the swelling degree was investigated. Konjac glucomannan and its mixture with kappa carrageenan film was immersed in GA solution and then thermally cured. The obtained cross-linked film was washed and soaked in the ethanol to remove the unreacted GA. The obtained film was air dried at room temperature to a constant weight. The infrared spectra and the value of swelling degree of obtained crosslinked film showed that glucomannan and kappa carrageenan was able to be cross-linked using glutaraldehyde by film immersion and curing method without catalyst. The cross-linked films were found to be pH sensitive, indicating a potential to be used in drug delivery polymer system.




References:
[1] K. Kato and K. Matsuka, “Studies on the chemical structure of konjac
mannan”, Agric. Biol. Chem., 1969, pp. 1446-1453.
[2] V.L. Campo, F.F. Kawano, D.B. Silva Junior, and I. Carvalho,
“Carrageenans: biological properties, chemical modifications and
structural analysis”, Carbohyd. Polym., 2009, pp. 167-180.
[3] G. Gerlach, M. Guenther, J. Sorber, G. Suchaneck, K. Arndt, and A.
Richter. “Chemical and pH sensors based on the swelling behavior of
hydrogels”, Sensor Actua B, 2005, pp. 555–561.
[4] Y. Samchenko, Z. Ulberg, and O. Korotych, O. “Multipurpose smart
hydrogel systems”, Adv. Colloid Interfac., 2011, pp. 247-262. [5] S. Distantina, Rochmadi, M. Fahrurrozi, and Wiratni. “Preparation and
Characterization of Glutaraldehyde-Crosslinked Kappa Carrageenan
Hydrogel”, Eng. J., Vol 17, 2013, pp. 57-66.
[6] S.B. Widjanarko, A. Nugroho, and Estiasih, T. “ Functional interaction
components of protein isolated and glucomanan in food bars by FTIR
and SEM studies”, African J. Food Sci., 2011, pp. 12-21.
[7] Q. Xu, W. Huang, L. Jiang, Z. Lei, X. Li, and H. Deng, “KGM and
PMAA based pH-sensitive interpenetrating polymer network hydrogel
for controlled drug release”, Carbohyd. Polym., 2013, pp. 565-570.
[8] A.N. Peppas, Hydrogels In: Biomaterial Science: an Introduction to
Material in Medicine, 2004, pp. 100-106, ed. Ratner et al., 2nd ed.
Elsevier Academic Press, California.
[9] K. Kim, S. Lee, S. And N.W. Han, “Kinetics of crosslinking reaction of
PVA membrane with glutaraldehyde”, Korean J. Chem. Eng., 1994, pp.
41-47.
[10] C.T. Lee, P.H. Kung, and Y.D. Lee, “Preparation of poly(vinyl alcohol)-
chondroitin sulfate hydrogel as matrices in tissue engineering”,
Carbohyd. Polym., 2005, pp. 348-354.
[11] H.S. Mansur, C.M. Sadahira, A.N. Souza, and A.A.P. Mansur, “FTIR
spectroscopy characterization of poly(vinyl alcohol) hydrogel with
different hydrolysis degree and chemically crosslinked with
glutaraldehyde”, Mat. Sci. Eng. C, 2008, pp.539-548.
[12] S. Rimdusit, K. Somsaeng, P. Kewsuwan, C. Jubsilp, and S.
Tiptipakorn, “Comparison of gamma radiation crosslinking and
chemical crosslinking on properties of methylcellulose hydrogel”, Eng.
J., 2012, pp. 15-28.