Noninvasive Assessment of Low Power Laser Radiation Effect on Skin Wound Healing Using Infrared Thermography
The goal of this paper is to examine the effects of laser
radiation on the skin wound healing using infrared thermography as
non-invasive method for the monitoring of the skin temperature
changes during laser treatment. Thirty Wistar rats were used in this
study. A skin lesion was performed at the leg on all rats. The animals
were exposed to laser radiation (λ = 670 nm, P = 15 mW, DP = 16.31
mW/cm2) for 600 s. Thermal images of wound were acquired before
and after laser irradiation. The results have demonstrated that the
tissue temperature decreases from 35.5±0.50°C in the first treatment
day to 31.3±0.42°C after the third treatment day. This value is close
to the normal value of the skin temperature and indicates the end of
the skin repair process. In conclusion, the improvements in the
wound healing following exposure to laser radiation have been
revealed by infrared thermography.
[1] G.S. Lazarus, D.M. Cooper, D.R. Knighton, D.J. Margolis, R.E. Pecoraro,
G. Rodeheaver, ÔÇ×et al Definitions and guidelines for assessment of
wounds and evaluation of healing," Arch Dermatol vol. 130, no. 4, pp.
489-493, 1994.
[2] E. Mester, T. Spiry, B. Szende, J.G. Tota, "Effect of laser rays on wound
healing," Am J Surg vol. 122, pp. 532-535, 1971.
[3] D. Hawkins, N. Houreld, H. Abrahamse, "Low Level Laser Therapy
(LLLT) as an Effective Therapeutic Modality for Delayed Wound
Healing," Ann NY Acad Sci vol. 1056, no.1, pp. 486-493, 2005.
[4] P.C. Lievens , "The effect of combined HeNe and IR laser treatment on
the regeneration of the lymphatic system during the process of wound
healing," Lasers Med Sci , vol. 6, no 2, pp. 193-199, 1991.
[5] J.T. Hopkins, T.A. McLoda, J.G. Seegmiller, G.D. Baxter, "Low-Level
Laser Therapy Facilitates Superficial Wound Healing in Humans: A
Triple-Blind, Sham-Controlled Study," J Athl Train vol. 39, no. 3, pp.
223-229, 2004.
[6] W. Posten, D.A. Wrone, J.S. Dover, K.A. Arndt, S. Silapunt, M. Alam,
"Low-level laser therapy for wound healing: mechanism and efficacy,"
Dermatol Surg vol. 31, no.3, pp. 334-340, 2005.
[7] E.Y.K. Ng, "A review of thermography as promising non-invasive
detection modality for breast tumor," Int J Therm Sci vol. 48, no.5, pp.
849-859, 2009.
[8] B. Kateb, V. Yamamoto, C. Yu, W. Grundfest, J.P. Gruen, "Infrared
thermal imaging: a review of the literature and case report,"
Neuroimage, vol. 47, 2009.
[9] G. Martini, K.J. Murray, K.J. Howell, J. Harper, D. Atherton, P. Woo,
"et al Juvenile-onset localized scleroderma activity detection by infrared
thermography," Rheumatology vol 41, pp. 1178-182, 2002.
[10] S.S. Han, C.H. Jung, S.C. Lee, H.J Jung, Y.H Kim, "Does skin
temperature difference as measured by infrared thermography within 6
months of acute herpes zoster infection correlate with pain level?" Skin
Research and Technolog, vol. 16, no. 2, pp.198 - 201, 2010.
[11] C. Hildebrandt, C. Raschner, K. Ammer, "An overview of recent
application of medical infrared thermography in sports medicine in
Austria" Sensors vol. 10, pp. 4700-4715, 2010.
[12] A. Hakg├╝der, M. Birtane, S. G├╝rcan, S. Kikino, F.N Turan, "Efficacy of
low level laser therapy in myofascial pain syndrome: An algometric and
thermographic evaluation," Lasers Surg Med vol. 33, no. 5, pp. 339 -
343, 2003.
[13] H. Fikácková, T. Dostálová, R. Vosická, V. Peterová, L. Navrátil, J.
Les├ík, ÔÇ×Arthralgia of the temporomandibular joint and low-level laser
therapy," Photomed Laser Surg vol. 24, no. 4, pp. 522-527, 2006.
[14] J. M. Bjordal, C. Couppè, R. Chow, J. Tunèr, A.E. Ljunggren, ÔÇ×A
systematic review of low level laser therapy with location-specific doses
for pain from chronic joint disorders" Aust J Physiother, vol. 49, no. 2,
pp. 107-116, 2003.
[15] A. Stergioulas, "Low -level laser treatment can reduce edema in second
degree ankle sprains," J Clin Laser Med Surg vol. 22, no. 2, pp. 125-
128, 2003.
[16] A. Schindl, M. Schindl, H. Pernerstorfer-Schön, U. Mossbacher,
L.Schindl, "Low intensity laser irradiation in the treatment of
recalcitrant radiation ulcers in patients with breast cancer - long-term
results of 3 cases," Photoderm Photoimmun Photomed vol. 16, no. 1,
pp. 34-37, 2000.
[17] D.M. Ferreira, R.A. Zangaro, A.B. Villaverde, Y. Cury, L. Frigo, G.
Picolo, "et al Analgesic effect of HeÔÇÉNe (632.8 nm) lowÔÇÉlevel laser
therapy on acute inflammatory pain," Photomed Laser Surg vol. 23, no.
2, pp. 177-188, 2005.
[18] R.G. Oliveira, F.M. Aarestrup, C. Miranda, B.J. Vieira, A.P. Ferreira,
L.C. Andrade, "Low-Level Laser Therapy Reduces Delayed
Hypersensitivity Reaction to Ovalbumin in Balb/C Mice," Photomed
Laser Surg vol. 28, no. 6, pp. 773-777, 2010.
[1] G.S. Lazarus, D.M. Cooper, D.R. Knighton, D.J. Margolis, R.E. Pecoraro,
G. Rodeheaver, ÔÇ×et al Definitions and guidelines for assessment of
wounds and evaluation of healing," Arch Dermatol vol. 130, no. 4, pp.
489-493, 1994.
[2] E. Mester, T. Spiry, B. Szende, J.G. Tota, "Effect of laser rays on wound
healing," Am J Surg vol. 122, pp. 532-535, 1971.
[3] D. Hawkins, N. Houreld, H. Abrahamse, "Low Level Laser Therapy
(LLLT) as an Effective Therapeutic Modality for Delayed Wound
Healing," Ann NY Acad Sci vol. 1056, no.1, pp. 486-493, 2005.
[4] P.C. Lievens , "The effect of combined HeNe and IR laser treatment on
the regeneration of the lymphatic system during the process of wound
healing," Lasers Med Sci , vol. 6, no 2, pp. 193-199, 1991.
[5] J.T. Hopkins, T.A. McLoda, J.G. Seegmiller, G.D. Baxter, "Low-Level
Laser Therapy Facilitates Superficial Wound Healing in Humans: A
Triple-Blind, Sham-Controlled Study," J Athl Train vol. 39, no. 3, pp.
223-229, 2004.
[6] W. Posten, D.A. Wrone, J.S. Dover, K.A. Arndt, S. Silapunt, M. Alam,
"Low-level laser therapy for wound healing: mechanism and efficacy,"
Dermatol Surg vol. 31, no.3, pp. 334-340, 2005.
[7] E.Y.K. Ng, "A review of thermography as promising non-invasive
detection modality for breast tumor," Int J Therm Sci vol. 48, no.5, pp.
849-859, 2009.
[8] B. Kateb, V. Yamamoto, C. Yu, W. Grundfest, J.P. Gruen, "Infrared
thermal imaging: a review of the literature and case report,"
Neuroimage, vol. 47, 2009.
[9] G. Martini, K.J. Murray, K.J. Howell, J. Harper, D. Atherton, P. Woo,
"et al Juvenile-onset localized scleroderma activity detection by infrared
thermography," Rheumatology vol 41, pp. 1178-182, 2002.
[10] S.S. Han, C.H. Jung, S.C. Lee, H.J Jung, Y.H Kim, "Does skin
temperature difference as measured by infrared thermography within 6
months of acute herpes zoster infection correlate with pain level?" Skin
Research and Technolog, vol. 16, no. 2, pp.198 - 201, 2010.
[11] C. Hildebrandt, C. Raschner, K. Ammer, "An overview of recent
application of medical infrared thermography in sports medicine in
Austria" Sensors vol. 10, pp. 4700-4715, 2010.
[12] A. Hakg├╝der, M. Birtane, S. G├╝rcan, S. Kikino, F.N Turan, "Efficacy of
low level laser therapy in myofascial pain syndrome: An algometric and
thermographic evaluation," Lasers Surg Med vol. 33, no. 5, pp. 339 -
343, 2003.
[13] H. Fikácková, T. Dostálová, R. Vosická, V. Peterová, L. Navrátil, J.
Les├ík, ÔÇ×Arthralgia of the temporomandibular joint and low-level laser
therapy," Photomed Laser Surg vol. 24, no. 4, pp. 522-527, 2006.
[14] J. M. Bjordal, C. Couppè, R. Chow, J. Tunèr, A.E. Ljunggren, ÔÇ×A
systematic review of low level laser therapy with location-specific doses
for pain from chronic joint disorders" Aust J Physiother, vol. 49, no. 2,
pp. 107-116, 2003.
[15] A. Stergioulas, "Low -level laser treatment can reduce edema in second
degree ankle sprains," J Clin Laser Med Surg vol. 22, no. 2, pp. 125-
128, 2003.
[16] A. Schindl, M. Schindl, H. Pernerstorfer-Schön, U. Mossbacher,
L.Schindl, "Low intensity laser irradiation in the treatment of
recalcitrant radiation ulcers in patients with breast cancer - long-term
results of 3 cases," Photoderm Photoimmun Photomed vol. 16, no. 1,
pp. 34-37, 2000.
[17] D.M. Ferreira, R.A. Zangaro, A.B. Villaverde, Y. Cury, L. Frigo, G.
Picolo, "et al Analgesic effect of HeÔÇÉNe (632.8 nm) lowÔÇÉlevel laser
therapy on acute inflammatory pain," Photomed Laser Surg vol. 23, no.
2, pp. 177-188, 2005.
[18] R.G. Oliveira, F.M. Aarestrup, C. Miranda, B.J. Vieira, A.P. Ferreira,
L.C. Andrade, "Low-Level Laser Therapy Reduces Delayed
Hypersensitivity Reaction to Ovalbumin in Balb/C Mice," Photomed
Laser Surg vol. 28, no. 6, pp. 773-777, 2010.
@article{"International Journal of Medical, Medicine and Health Sciences:64952", author = "M.A. Calin and S.V. Parasca and M.R. Calin and D. Savastru and D. Manea", title = "Noninvasive Assessment of Low Power Laser Radiation Effect on Skin Wound Healing Using Infrared Thermography", abstract = "The goal of this paper is to examine the effects of laser
radiation on the skin wound healing using infrared thermography as
non-invasive method for the monitoring of the skin temperature
changes during laser treatment. Thirty Wistar rats were used in this
study. A skin lesion was performed at the leg on all rats. The animals
were exposed to laser radiation (λ = 670 nm, P = 15 mW, DP = 16.31
mW/cm2) for 600 s. Thermal images of wound were acquired before
and after laser irradiation. The results have demonstrated that the
tissue temperature decreases from 35.5±0.50°C in the first treatment
day to 31.3±0.42°C after the third treatment day. This value is close
to the normal value of the skin temperature and indicates the end of
the skin repair process. In conclusion, the improvements in the
wound healing following exposure to laser radiation have been
revealed by infrared thermography.", keywords = "skin, wound, laser, thermal image", volume = "5", number = "11", pages = "640-4", }
