Grape Seed Extract in Prevention and Treatment of Liver Toxic Cirrhosis in Rats

The liver is the strongest regenerating organ of the
organism, and even with 2/3 surgically removed, it can regenerate
completely. Hence liver cirrhosis may only develop when the
regenerating system is off.
We present the results of a comparative study of structural and
functional characteristics of rat liver tissue under the conditions of
toxic liver cirrhosis development, induced by carbon tetrachloride,
and its prevention/treatment by natural compounds with antioxidant
and immune stimulating action. Studies were made on Wister rats,
weighing 120~140 g. Grape seeds extracts, separately and in
combination with well-known anticirrhotic drug ursodeoxycholic
acid (Urdoxa), have demonstrated effectiveness in prevention of liver
cirrhosis development and its treatment.

• S. Buloyan
• V. Mamikonyan
• H. Hakobyan
• H. Harutyunyan
• H. Gasparyan

• Carbon tetrachloride
• GSE
• liver cirrhosis
• prevention
• treatment.

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