Comparative Evaluation of the Biopharmaceutical and Chemical Equivalence of the Some Commercial Brands of Paracetamol Tablets

Acetaminophen (Paracetamol) tablets are popular OTC products among patients as analgesics and antipyretics. Paracetamol is marketed by a lot of suppliers around the world. The aim of the present investigation was to compare between many types of paracetamol tablets obtained from different suppliers (six brands produced by different pharmaceutical companies in middle east countries, and Panadol® manufactured in Ireland), by different quality control tests according to USP pharmacopeia.Using Non official tests-hardness and friability; official tests- disintegration, dissolution, and drug content. Additionally, evaluate the influence of temperatures 4°C, 25°C and 40°C at 75% relative humidity on the stability of the same brands in their original packaging has been conducted for two months. The results revealed that all paracetamol tablet brands complied with the official USP specifications. In conclusion, paracetamol tablets preferred to be stored at 25°C. All the tested brands being biopharmaceutically and chemically equivalent.

• Raniah Al-Shalabi
• Omaima Al- Gohary
• Samar Afify
• Eram Eltahir

• Non official tests-hardness and friability
• official tests –disintegration
• dissolution
• and drug content.

[1] Yogananda R, Nagaraja TS, Snehalatha, Jayadevaiah KV, Vijay Kumar
MMJ, Comparative in vitro equivalence studies of designed, branded
and generic tablets of ciprofloxacin-250, Int J Pharm Sci, 2009, pp. 28-
34.
[2] Malviya R., Srivastava P., preparation and evaluation of disintegrating
properties of Cucurbita Maxima Pulp powder. International journal of
pharmaceutical sciences, 2010, pp.119.
[3] Weise AM., Liu CY., Shield A.F, fatal liver failure in a patient on
acetaminophen treated with sunitinib malate and levothyroxine.Ann
pharmacother, 2009, 43(4):761-766.
[4] Lawrence J.,Moore E.,Port L.,Danchin M.,paracetamol as a risk factor
for allergic disorders.The lancet,2009,pp.119-119.
[5] Persky V.,Piorkowski J., Hermandoz E.,parental exposure to
acetaminophen and respiratory symptoms in the first year of life.Ann
Aleegy Asthma Immunol,2008,101(3):271-278.
[6] Bamigbola EA., Ibrahim MA., Attama AA., comparative in-vitro
assessment of soluble and plain brands of aspirin tablets marketed in
Nigeria.Sci Res Essay, 2009, 11(4):1412-1414.