Abstract: Medical Decision Support Systems (MDSSs) are sophisticated, intelligent systems that can provide inference due to lack of information and uncertainty. In such systems, to model the uncertainty various soft computing methods such as Bayesian networks, rough sets, artificial neural networks, fuzzy logic, inductive logic programming and genetic algorithms and hybrid methods that formed from the combination of the few mentioned methods are used. In this study, symptom-disease relationships are presented by a framework which is modeled with a formal concept analysis and theory, as diseases, objects and attributes of symptoms. After a concept lattice is formed, Bayes theorem can be used to determine the relationships between attributes and objects. A discernibility relation that forms the base of the rough sets can be applied to attribute data sets in order to reduce attributes and decrease the complexity of computation.
Abstract: Malaria is by far the world-s most persistent tropical parasitic disease and is endemic to tropical areas where the climatic and weather conditions allow continuous breeding of the mosquitoes that spread malaria. A mathematical model for the transmission of malaria with prophylaxis prevention is analyzed. The stability analysis of the equilibria is presented with the aim of finding threshold conditions under which malaria clears or persists in the human population. Our results suggest that eradication of mosquitoes and prophylaxis prevention can significantly reduce the malaria burden on the human population.
Abstract: Autofluorescence (AF) bronchoscopy is an
established method to detect dysplasia and carcinoma in situ (CIS).
For this reason the “Sotiria" Hospital uses the Karl Storz D-light
system. However, in early tumor stages the visualization is not that
obvious. With the help of a PC, we analyzed the color images we
captured by developing certain tools in Matlab®. We used statistical
methods based on texture analysis, signal processing methods based
on Gabor models and conversion algorithms between devicedependent
color spaces. Our belief is that we reduced the error made
by the naked eye. The tools we implemented improve the quality of
patients' life.
Abstract: Von Willebrand-s disease is the most common
inherited bleeding disorder in humans, it
caused by qualitative abnormalities of the von Willebrand factor
(vWF). Our objective is to determine the prevalence of this disease at
part of the Algerian population in the East and the South by a
biological diagnosis based on specific biological tests (automated
platelet count, the bleeding time (TS), the time of cephalin + activator
(TCA), measure of the prothrombin rate (TP), vWF rate and factor
VIII rate, Molecular electrophoresis of vWF multimers in agarose gel
in the presence of SDS). Four patients of type III or severe
Willebrand-s disease were found on 200 suspect cases. All cases are
showed a deficit in vWF rate (< 5%), and factor VIII (P
Abstract: We have developed a computer program consisting of
6 subtests assessing the children hand dexterity applicable in the
rehabilitation medicine. We have carried out a normative study on a
representative sample of 285 children aged from 7 to 15 (mean age
11.3) and we have proposed clinical standards for three age groups
(7-9, 9-11, 12-15 years). We have shown statistical significance of
differences among the corresponding mean values of the task time
completion. We have also found a strong correlation between the task
time completion and the age of the subjects, as well as we have
performed the test-retest reliability checks in the sample of 84
children, giving the high values of the Pearson coefficients for the
dominant and non-dominant hand in the range 0.740.97 and
0.620.93, respectively.
A new MATLAB-based programming tool aiming at analysis of
cardiologic RR intervals and blood pressure descriptors, is worked
out, too. For each set of data, ten different parameters are extracted: 2
in time domain, 4 in frequency domain and 4 in Poincaré plot
analysis. In addition twelve different parameters of baroreflex
sensitivity are calculated. All these data sets can be visualized in time
domain together with their power spectra and Poincaré plots. If
available, the respiratory oscillation curves can be also plotted for
comparison. Another application processes biological data obtained
from BLAST analysis.
Abstract: NFκB is a transcription factor regulating many
function of the vessel wall. In the normal condition , NFκB is
revealed diffuse cytoplasmic expressionsuggesting that the system is
inactive. The presence of activation NFκB provide a potential
pathway for the rapid transcriptional of a variety of genes encoding
cytokines, growth factors, adhesion molecules and procoagulatory
factors. It is likely to play an important role in chronic inflamatory
disease involved atherosclerosis. There are many stimuli with the
potential to active NFκB, including hyperlipidemia. We used 24 mice
which was divided in 6 groups. The HFD given by et libitum
procedure during 2, 4, and 6 months. The parameters in this study
were the amount of NFKB activation ,H2O2 as ROS and VCAM-1 as
a product of NFKB activation. H2O2 colorimetryc assay performed
directly using Anti Rat H2O2 ELISA Kit. The NFKB and VCAM-1
detection obtained from aorta mice, measured by ELISA kit and
imunohistochemistry. There was a significant difference activation of
H2O2, NFKB and VCAM-1 level at induce HFD after 2, 4 and 6
months. It suggest that HFD induce ROS formation and increase the
activation of NFKB as one of atherosclerosis marker that caused by
hyperlipidemia as classical atheroschlerosis risk factor.
Abstract: This study examined the effects of eight weeks of
whole-body vibration training (WBVT) on vertical and decuple jump
performance in handball athletes. Sixteen collegiate Level I handball
athletes volunteered for this study. They were divided equally as
control group and experimental group (EG). During the period of the
study, all athletes underwent the same handball specific training, but
the EG received additional WBVT (amplitude: 2 mm, frequency: 20 -
40 Hz) three time per week for eight consecutive weeks. The vertical
jump performance was evaluated according to the maximum height of
squat jump (SJ) and countermovement jump (CMJ). Single factor
ANCOVA was used to examine the differences in each parameter
between the groups after training with the pretest values as a covariate.
The statistic significance was set at p < .05. After 8 weeks WBVT, the
EG had significantly improved the maximal height of SJ (40.92 ± 2.96
cm vs. 48.40 ± 4.70 cm, F = 5.14, p < .05) and the maximal height
CMJ (47.25 ± 7.48 cm vs. 52.20 ± 6.25 cm, F = 5.31, p < .05). 8 weeks
of additional WBVT could improve the vertical and decuple jump
performance in handball athletes. Enhanced motor unit
synchronization and firing rates, facilitated muscular contraction
stretch-shortening cycle, and improved lower extremity
neuromuscular coordination could account for these enhancements.
Abstract: This study examined the effects of neuromuscular
training (NT) on limits of stability (LOS) in female individuals.
Twenty female basketball amateurs were assigned into NT
experimental group or control group by volunteer. All the players were
underwent regular basketball practice, 90 minutes, 3 times per week
for 6 weeks, but the NT experimental group underwent extra NT with
plyometric and core training, 50 minutes, 3 times per week for 6 weeks
during this period. Limits of stability (LOS) were evaluated by the
Biodex Balance System. One factor ANCOVA was used to examine
the differences between groups after training. The significant level for
statistic was set at p
Abstract: Background: Regular physical activity contributes
positively to physical and psychological health. In the present study,
the stages of change of physical activity and the total physical
Aims: The aim of this study was to investigate the proportion of
adolescent girls in each stages of change and the causative factors
associated with physical activity such as the related social support
and self efficacy in a sample of the high school students.
Methods: In this study, Social Cognitive Theory (SCT) and the
Transtheorical Model (TTM) guided instrument development. The
data regarding the demographics, psychosocial determinants of
physical activity, stage of change and physical activity was gathered
by questionnaires. Several measures of psychosocial determinants of
physical activity were translated from English into Persian using the
back-translation technique. These translated measures were
administered to 512 ninth and tenth-grade Iranian high school
students for factor analysis.
Results: The distribution of the stage of change for physical activity
was as follow: 18/5% in precontemplation, 23.4% in contemplation,
38.2% in preparation, 4.6% in action and 15.3% in maintenance.
They were in 80.1% pre-adoption stages (precontemplation stage,
contemplation stage and preparation stage) and 19.9% post-adoption
stages (action stage and maintenance stage) of physical activity.
There was a significant relate between age and physical activity in
adolescent girls (age-related decline of physical activity) p
Abstract: These All pig-producing countries from around the world report the presence of Postweaning multisystemic wasting syndrome (PMWS.) In America, PCV2 has been recognized in Canada, United States and Brazil. Knowledge concerning the genetic sequences of PMWS has been very important. In Mexico, there is no report describing the genetic sequences and variations of the PCV2 virus present around the country. For this reason, the main objective was to describe the homology and genetic sequences of the PCV2 virus obtained from different regions of Mexico. The results show that in Mexico are present both subgenotypes \"a\" and \"b\" of this virus and the homologies are from 89 to 99%. Regarding with the aminoacid sequence, three major heterogenic regions were present in the position 59-91, 123–136 and 185–210. This study presents the results of the first genetic characterization of PCV2 in production herds from Mexico.
Abstract: The colonic tissue is a complicated dynamic system
and the colonic activities it generates are composed of irregular
segmental waves, which are referred to as erratic fluctuations or spikes.
They are also highly irregular with subunit fractal structure. The
traditional time-frequency domain statistics like the averaged
amplitude, the motility index and the power spectrum, etc. are
insufficient to describe such fluctuations. Thus the fractal
box-counting dimension is proposed and the fractal scaling behaviors
of the human colonic pressure activities under the physiological
conditions are studied. It is shown that the dimension of the resting
activity is smaller than that of the normal one, whereas the clipped
version, which corresponds to the activity of the constipation patient,
shows with higher fractal dimension. It may indicate a practical
application to assess the colonic motility, which is often indicated by
the colonic pressure activity.
Abstract: The purpose of my research proposal is to
demonstrate that there is a relationship between EEG and
endometrial cancer.
The above relationship is based on an Aristotelian Syllogism;
since it is known that the 14-3-3 protein is related to the electrical
activity of the brain via control of the flow of Na+ and K+ ions and
since it is also known that many types of cancer are associated with
14-3-3 protein, it is possible that there is a relationship between EEG
and cancer. This research will be carried out by well-defined
diagnostic indicators, obtained via the EEG, using signal processing
procedures and pattern recognition tools such as neural networks in
order to recognize the endometrial cancer type. The current research
shall compare the findings from EEG and hysteroscopy performed on
women of a wide age range. Moreover, this practice could be
expanded to other types of cancer. The implementation of this
methodology will be completed with the creation of an ontology.
This ontology shall define the concepts existing in this research-s
domain and the relationships between them. It will represent the
types of relationships between hysteroscopy and EEG findings.
Abstract: Expression and secretion of inflammation markers are
disturbed in obesity. Interleukin-6 reduces body fat mass. The
common G-174C polymorphism in the promoter of IL-6 gene has
been reported that effects on transcriptional regulation. The objective
was to investigate association of the common polymorphism G-174C
with obesity in Iranian population. The present study is cross
sectional association study that included 242 individuals (110 men
and 132 women). Serum IL-6 levels, C-reactive protein, fasting
blood glucose and blood lipids profile were measured .BMI and
WHR were calculated. Genotyping is carried out by PCR and RFLP.
The frequencies of G and C allele were 64.5% and 35.5%,
respectively. The G-174C polymorphism was not associated with
BMI and WHR. However in obese individual, fasting blood glucose
was significantly higher in carrier of C allele compared with the noncarrier.
The IL-6 G-174C polymorphism is not a risk factor for
obesity in Iranian population.
Abstract: In this paper we present a novel approach for wavelet compression of electrocardiogram (ECG) signals based on the set partitioning in hierarchical trees (SPIHT) coding algorithm. SPIHT algorithm has achieved prominent success in image compression. Here we use a modified version of SPIHT for one dimensional signals. We applied wavelet transform with SPIHT coding algorithm on different records of MIT-BIH database. The results show the high efficiency of this method in ECG compression.
Abstract: The nature, prevalence, cellular composition of
leukocyte infiltrates and immunohistochemical characteristics of
their constituent cells in the liver of patients with chronic viral
hepatitis B and C were investigated. It was found that the area of
distribution and cellular composition of infiltrates depended on the
virus type and process activity. The expediency of
immunohistochemical study using leukocyte infiltrates from liver
biopsies of patients with viral hepatitis aimed at clarifying diagnosis,
making prognosis, and choice of optimal treatment with elements of
immune correction is emphasized.
Abstract: In elevating performance in competetive sports, an
athlete must continously train in achieving maximum
performance,but needs to pay attention to recovery therapy, that is to
recover from fatigue as well as injury.The correct recovery therapy
will assist in process of recovery and helps in the training in
achieving better performace. Binahong (Anredera cordifolia) was
proven empirically by the locals in assisting speedy recovery from an
injury.Clinical research with lab animals receiving blunt trauma
injury, microscopically shown signs of: 1) redness, 2) heatiness, 3)
swelling and, 4) lack of activity. There is also microscopic indication
of: 1) infiltration of inflame cells (migration of cells to the trauma
area), 2) Cells necrosis, 3) Congestion (as a result of dead red blood
cells), 4) uedema. On administration of Binahong for 3 days, there is
a significant drop of 5% in cell inflammation, 2% increase of
fibroblast (cell membrance) count.Conclutin: Binahong do assist in
reducing cell inflammation and increase counts of cells fibroblast.
Suggestion: In helping athlete's to recover from force injury, we need
study about Binahong's roots to inflammation cell and healing of
injuried cell.
Abstract: Dexamethasone (Dex) is a synthetic glucocorticoid
that is used in therapy. However prolonged treatments with high
doses are often required. This causes side effects that interfere with
the activity of several endocrine systems, including the gonadotropic
axis.
The aim of our study is to determine the effect of Dex on testicular
function in prepubertal Wistar rats.
Newborn Wistar rats are submitted to intraperitoneal injection of
Dex (1μg of Dex dissolved in NaCl 0.9% / 5g bw) for 20 days and
then sacrificed at the age of 40days. A control group received NaCl
0.9%. The rat is weighed daily. The plasmatic levels of testosterone,
LH and FSH were measured by radioimmunoassay. A histomorphometric
study was performed on sections of testis.
Treated groups showed a significant decrease in body weight (p
Abstract: This article provides partial evaluation index and its
standard of sports aerobics, including the following 12 indexes: health
vitality, coordination, flexibility, accuracy, pace, endurance, elasticity,
self-confidence, form, control, uniformity and musicality. The
three-layer BP artificial neural network model including input layer,
hidden layer and output layer is established. The result shows that the
model can well reflect the non-linear relationship between the
performance of 12 indexes and the overall performance. The predicted
value of each sample is very close to the true value, with a relative
error fluctuating around of 5%, and the network training is successful.
It shows that BP network has high prediction accuracy and good
generalization capacity if being applied in sports aerobics performance
evaluation after effective training.
Abstract: Functional imaging procedures for the non-invasive assessment of tissue microcirculation are highly requested, but require a mathematical approach describing the trans- and intercapillary passage of tracer particles. Up to now, two theoretical, for the moment different concepts have been established for tracer kinetic modeling of contrast agent transport in tissues: pharmacokinetic compartment models, which are usually written as coupled differential equations, and the indicator dilution theory, which can be generalized in accordance with the theory of lineartime- invariant (LTI) systems by using a convolution approach. Based on mathematical considerations, it can be shown that also in the case of an open two-compartment model well-known from functional imaging, the concentration-time course in tissue is given by a convolution, which allows a separation of the arterial input function from a system function being the impulse response function, summarizing the available information on tissue microcirculation. Due to this reason, it is possible to integrate the open two-compartment model into the system-theoretic concept of indicator dilution theory (IDT) and thus results known from IDT remain valid for the compartment approach. According to the long number of applications of compartmental analysis, even for a more general context similar solutions of the so-called forward problem can already be found in the extensively available appropriate literature of the seventies and early eighties. Nevertheless, to this day, within the field of biomedical imaging – not from the mathematical point of view – there seems to be a trench between both approaches, which the author would like to get over by exemplary analysis of the well-known model.
Abstract: The linear SEF (Spectral Edge Frequency) parameter
and spectrum analysis method can not reflect the non-linear of EEG.
This method can not contribute to acquire real time analysis and obtain
a high confidence in the clinic due to low discrimination. To solve the
problems, the development of a new index is carried out using the
bispectrum analyzing the EEG(electroencephalogram) including the
non-linear characteristic. After analyzing the bispectrum of the 2
dimension, the most significant power spectrum density peaks appeared abundantly at the specific area in awakening and anesthesia state. These points are utilized to create the new index since many
peaks appeared at the specific area in the frequency coordinate. The measured range of an index was 0-100. An index is 20-50 at an anesthesia, while the index is 90-60 at the awake. New index could afford to effectively discriminate the awake and anesthesia state.